To investigate the clinical significance of MARVELD1 in lung cancer, immunohistochemical analysis was performed in total 194 cases of lung cancer specimen, including 55 cases of small cell lung cancer (SCLC) specimen, 35 cases of adenocarcinoma specimen, 44 cases of squamous cell carcinoma specimen, 20 cases of adenosquamous carcinoma specimen, 20 cases of bronchioalveolar cell carcinoma specimen, 20 cases of large cell lung carcinoma specimen and their adjacent lung tissues with MARVELD1 specific antibody. The gene discussed is MARVELD1; the disease is lung large cell carcinoma.