Moreover, we constructed the NMD reporter plasmid expressing PTC-containing truncated LRP1B-GFP mRNA (LRP1B exons 1–9 from lung cancer cell line QG56), and demonstrated that MARVELD1 bound PTC-mRNA as efficient as NMD core factor UPF1 and SMG1 by RNA-ChIP based reporter system. This evidence concerns the gene SMG1 and lung cancer.