To examine whether MARVELD1 affected NMD, we generated a NMD reporter plasmid carrying a PTC derived from deletion mutation of endogenous LRP1B gene exons 1–9 in lung cancer cell QG56 (Figure S4); GFP-coding region was inserted at C-terminal of LRP1B gene (Figure 5a). The gene discussed is MARVELD1; the disease is lung carcinoma.