Catalina et al. evaluated the apoptotic effects of CellfoodTM (CF), a nutritional supplement containing deuterium sulphate, minerals, amino acids, and enzymes, on three leukemic cell lines including Jurkat, U937, and K562 cells, and reported that this natural anti-oxidant extracted from the red algae Lithothamnion calcareum, modulates cell signalling and apoptosis in cancer cells by activating caspase 3, inducing nucleosomal DNA frangmentation, and altering cell metabolism through down-regulation of HIF-1α and GLUT-1 expression [75]. This evidence concerns the gene CASP3 and cancer.