TTK and neoplasm: Using a combined geneset of these 5 remaining cell cycle-related genes (BUB1B, CCNB1, CCNB2, TTK and CDK1) as well as ADAM7 and FAM72B, we also observed a statistically-significant reduction in disease-free survival of patients with tumours exhibiting alterations in gene expression (p = 0.015) (Figure 3D).