Finally, we identify a biomarker panel of 7 genes (ADAM7, FAM72B, BUB1B, CCNB1, CCNB2, TTK and CDK1), which included a cell cycle-related geneset, that was not only mis-regulated in a significant proportion of treatment-naïve PCa specimens, but also associated with early relapse after treatment. Here, CCNB2 is linked to posterior cortical atrophy.