USP7 and large cell carcinoma: In NSCLC, Masuya et al. reported that USP7 mRNA expression was significantly lower in adenocarcinomas than in squamous cell carcinomas, and 45.0 % patients showed reduced expression of USP7 and the reduction of USP7 gene expression was reported to play an important role in adenocarcinomas through p53-dependent pathways [8], However, the detailed roles of USP7 in NSCLC should be performed to clarify, for example, the expression of USP7 in NSCLC compared with the corresponding non-tumorous tissues and its roles and mechanisms in lung squamous cell carcinomas and large cell carcinoma.