Major neuropathological and neurochemical hallmarks of this autosomal dominant hereditary disease included extracellular accumulation of mutated transthyretin (TTR) aggregates and amyloid fibers, particularly in autonomic and peripheral nervous systems (ANS and PNS, respectively), leading to sensorimotor, motor and autonomic neuropathy [2]. The gene discussed is TTR; the disease is autonomic neuropathy.