For ccRCC patients with either high uPA (HR = 2.86; 95% CI 1.07-7.67; P = 0.037) or uPAR antigen levels (HR = 4.70; 95% CI 1.51-14.6; P = 0.008) we observed a significantly increased risk of cancer-related death compared with those patients who displayed low uPA or uPAR antigen levels in ccRCC tissue (Table 3). The gene discussed is PLAU; the disease is nonpapillary renal cell carcinoma.