Moreover, in multivariate analyses using the base model mentioned above (comprising gender, age, tumour stage and tumour grade), we found that combined high antigen levels of uPA and/or uPAR resulted in an even better prediction of DSS represented by a HR of 14.5 (95% CI 1.88-111.1, P = 0.010), which was independent of other factors (Table 4). This evidence concerns the gene PLAU and neoplasm.