The most significant pathways (n = 22; P <0.005) are presented in Table 2B, and include protein kinase A signaling, G-protein coupled receptor signaling, T cell receptor and anergic T lymphocyte regulation, estrogen-dependent breast cancer and GNRH signaling, as well as pathways related to cardiac hypertrophy and melanocyte development to name a few. The gene discussed is GNRH1; the disease is breast cancer.