Of the GO term enrichments that are shared by all three species (Group B2, Figure 7; green; Additional file 1: Table S15B2) a subset (31%) are also associated with genes that are either lethal in mice, or related to human genetic diseases or disorders (Additional file 1: Tables S12 and 13 in), including CEBPE (congenital granule deficiency), STXBP2 (hemophagocytic lymphohistiocytosis), and ATP2B3 (spinocerebellar ataxia). The gene discussed is STXBP2; the disease is hemophagocytic syndrome.