Genes associated with GO terms in Group B1 (Additional file 1: Table S15B1) were: NPHS1, a gene whose loss in humans leads to nephrosis; NR1H2, a key regulator of macrophage function; and KIRREL2, a novel immunoglobin gene that is expressed chiefly in beta cells of the pancreatic islets. This evidence concerns the gene NPHS1 and nephrosis.