CTNND1 and neoplasm: Supplementary Fig. 1c–f shows that the three individual siRNAs affected metaphase plate formation in a similar way as the siRNA pool and also led to reduced junctional p120 catenin staining in mitotic cells. We could not test the specificity by complementation as transfection of DLC2 inhibited G1 exit as previously published26. Hence, DLC2 seems to regulate spindle assembly, possibly involving interplay between the spindle and the cell cortex. DLC2 was first reported as a tumour suppressor in liver cancer and is repressed in various other cancers27, 28, 29.