RB1 and leukemia: Among the 39 genes that are uniquely contained in Module 1 of the all-leukemia network (Additional files 6 and 7) are a number of well-characterized oncogenes, such as Ar, Bmi1, ETS1, Kit, Lin28a, as well as tumor repressor genes, such as Rb1. The all-leukemia network also contains an additional module, Module 2, which is likely to be regulated independently of Module 1.