Five of nine patients (seven patients with advanced melanoma, one metastatic synovial cell carcinoma and one advanced esophageal carcinoma) treated with gene-modified T cells using a HLA-A*0201-restricted melanoma antigen family A3 (MAGE-A3)-specific TCR demonstrated tumor regression, but two patients died of severe central nervous system damage [25]. This evidence concerns the gene MAGEA3 and melanoma.