LIPE and neoplasm: Similar chromatographs were observed for all purified hEx3-scDb-Fcs (Fig. 1C); however, hEx3-scDb-Fcs with the VL–VH order (hEx3-scDb-Fc-LHs) inhibited tumor cell growth more effectively than did those with the VH-VL order (hEx3-scDb-Fc-HLs) (Fig. 2A).