The IgG2 subtype of hEx3-scDb-Fc-LH showed comparable in vitro and in vivo functions to those of the IgG1 subtype, with the exception of its proliferative effects on PBMCs (Figs. 7and8; Table 1), suggesting that Fc-mediated effector functions such as ADCC are not essential for the induction of the effective anti-tumor activity of hEx3-scDb-Fc-LH. This evidence concerns the gene PLOD1 and neoplasm.