In the present study, we made use of large available datasets containing metagenomic information from populations of patients with IBD, diabetes and controls individuals to determine whether there are differences in the abundance of bacterial genes involved in the deconjugation (bsh), dehydroxylation and epimerization (adh and hsdh) of bile acids within the diseased microbiomes. The gene discussed is SDS; the disease is inflammatory bowel disease.