In this study, we replicated these SNPs (rs6543116, -27307T/A, -27614C/A) and examined another three SNPs (rs951774, rs10515922, and 13006559) in the distal promoter region, which were selected by extending 30 kb into the 5' end of ST2. We also analyzed the tagSNPs in the ST2 gene to explore the genetic role of ST2 in the pathogenesis of CHD. Here, IL1RL1 is linked to coronary artery disorder.