In 48% of samples (n = 13, 8 complex carcinomas, 4 carcinomas in benign tumour and 1 simple carcinoma), PRA mRNA expression was between 3 and 10 times higher than PRB mRNA expression on day 1; PRA expression was also significantly higher than PRB expression in 80% of tumours (n = 4) in the control group and 82% in the experimental group (n = 18) (P = 0.003). The gene discussed is RB1; the disease is carcinoma.