Because contraction of the materials in PED after treatment with an anti-VEGF drug or PDT along with increased tension in the RPE monolayer resulting in detachment of the vascularized RPE due to leakage from the CNV may be crucial steps in the development of RPE tears, cases with AMD in which a cleft emerges may need to be closely observed for the development of RPE tear. Here, VEGFA is linked to age-related macular degeneration.