Consistent with the argument for an important role of VEGF in osteoarthritis, Gallelli et al. showed that ibuprofen, diclofenac and celecoxib decrease VEGF levels in the synovial fluid of the osteoarthritic joint, with a concomitant improvement in joint pain as well as joint function in osteoarthritis patients[33]. The gene discussed is VEGFA; the disease is osteoarthritis.