There is evidence supporting that high VEGF levels in both plasma and synovial fluids are positively correlated with the radiographic severity of knee osteoarthritis, suggesting increased expression of VEGF occurs in osteoarthritis cartilage, and this may stimulate the growth of blood vessels from subchondral bone into articular cartilage, thereby contributing to osteoarthritis progression[18]. The gene discussed is VEGFA; the disease is osteoarthritis, knee.