SERPINF2 and infection: Compared to wild type mice, bacterial spreading in α2AP KO mice was similar in the early stages of the infection, but was more pronounced at day 9 (P < 0.05) (Figure 3B), resulting in an increase in macroscopic lesion size at day 10 (31.8 ± 20.9 mm2 in α2AP KO/null mice (n = 11) vs. 19.2 ± 9.7 mm2 in WT/null mice (n = 12), P = 0.078) (Figure 3A).