Fig. 2B shows quantitative results for the number of vessels stained with CD31 or α-SMA Ab (/200x field) and reveals that CD and AD were significantly lower in LOX-1 KO mice than in WT mice (CD31: WT vs. LOX-1 KO: 906.6±71.0 vs. 481.1±72.6, p<0.01, α-SMA: WT vs. LOX-1 KO: 163.6±33.2 vs. 85.0±27.7, p<0.01). This evidence concerns the gene ACTA1 and Alzheimer disease.