The precise mechanism of VEGF secretion via LOX-1 has not been elucidated yet, but it has been reported that oxidized phospholipids stimulate angiogenesis via autocrine mechanisms involving VEGF in advanced atherosclerotic lesions [40] and that chondrocytes stimulated by oxidized LDL via LOX-1 secrete VEGF [41]. This evidence concerns the gene OLR1 and Atherosclerotic lesion.