Alzheimer's disease (AD) is the most common cause of dementia in the elderly.1 Currently, there is no effective therapeutic modality for the prevention, halting or reversal of AD.2 The two principal neuropathological hallmarks of AD are the accumulation of extracellular plaques of β-amyloid (Aβ) peptides and intracellular neurofibrillary tangles of hyperphosphorylated tau protein in the brain. Here, MAPT is linked to Alzheimer disease.