Treatment in patients with HF included angiotensin-converting enzyme inhibitors in 53 cases (60%), AT1 blockers in 21 cases (24%), β-blockers in 81 cases (91%), diuretics in 59 cases (66%), antialdosteronic drugs in 43 cases (48%), amiodarone in 37 cases (42%), digoxin in 4 cases (5%), antiplatelet in 59 cases (66%), and anticoagulant in 24 cases (27%). The gene discussed is ACE; the disease is hydrops fetalis.