Nevertheless, although the lead compound was identified through synthetic lethality screening using KRAS mutant cells [19], the anticancer activity of NSC-743380 in the NCI-60 cell panel and in 50 human non–small cell lung carcinoma cell lines did not show a significant correlation with KRAS mutations, because a substantial number of KRAS wild-type cancer cells were also highly susceptible to NSC-743380 [20, 25]. Here, KRAS is linked to cancer.