TTR and neoplasm: Univariate and multivariate analyses showed that PKM2 expression in tumor cells served as an independent risk factor for both OS (P < 0.001, HR = 2.117; P = 0.001, HR = 1.901, respectively) and TTR (P < 0.001, HR = 1.742; P = 0.018, HR = 1.451, respectively; Table 2).