In our study, we found that PKM2 promoted HCC progression in a nude mouse xenograft model by recruiting Gr-1+CD11b+ granulocytic MDSCs, F4/80+ CD11b+ macrophages, and Ly6C+ CD11b+ monocytic MDSCs to the tumor microenvironment. The gene discussed is ITGAM; the disease is hepatocellular carcinoma.