3, Specific inhibition of NHE1 potentiates effects of paclitaxel: We found that two structurally different NHE1 inhibitors, EMD87580 [(2-methyl-4,5-di-(methylsulfonyl)-benzoyl)-guanidine], and HMA [5-(N, N-hexamethylene)-amiloride] specifically potentiated effects of paclitaxel on triple-negative breast cancer cells. The gene discussed is SLC9A1; the disease is triple-negative breast carcinoma.