In summary, this study highlights the role of exogenous H2S supplementation in MI-induced myocardial remodeling and cardiac dysfunction, and has shown that exogenous H2S therapy suppresses extracellular matrix accumulation and induces new vessels growth in the border zone of infarct area, at least in part, through modulation of HO-1 and CSE expression. This evidence concerns the gene HMOX1 and myocardial infarction.