Because defect in synaptic vesicles was known to be one of the earliest event in ALS pathology [15] and the potential involvement of AAK1 in ALS pathology is completely unknown, we decided to better understand the potential role of AAK1 in ALS in general by first characterizing AAK1 expression in the spinal cord of the rodent models of SOD1-linked ALS, the knowledge of which has not been established previously. Here, SOD1 is linked to amyotrophic lateral sclerosis.