Because transgenic mouse and rat models of SOD1-linked ALS with different SOD1 mutants have been well-established and both are phenotypically representative of ALS pathology [4], we chose SOD1G85R transgenic mouse and SOD1G93A transgenic rat lines to focus on examining the commonality of AAK1 expression in rodent spinal cords that are most relevant to ALS pathology. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.