In conclusion, our results represent the first demonstration that NR5A2 rs3790844 polymorphism was associated with the increased OS of GC patients in the dominant model, and similar results were found among the female patients group and tumor size >5 cm group for the NR5A2 rs3790843 polymorphism, suggesting that the mutant alleles may serve as suitable markers for predicting the survival of gastric cancer patients, especially in a Chinese population. This evidence concerns the gene NR5A2 and neoplasm.