Further, NR5A2 expression is elevated in pancreatic cancer andpromotes pancreatic cancer cell growth through stimulation of cyclin D1, cyclin E1 and c-Myc [15], while genome-wide association studies implicate mutations in the NR5A2 gene in pancreatic ductal adenocarcinoma [16]. This evidence concerns the gene CCNE1 and familial pancreatic carcinoma.