This is confirmed by the finding reported by Dr. Bu group, which demonstrated, in a conditional LRP-1-deleted mouse model, that LRP-1 is a major Aβ clearance receptor in cerebral vascular smooth muscle cells (vSMCs), and its malfunction contributes to Aβ accumulation and the pathogenesis of Alzheimer disease [71]. The gene discussed is LRP1; the disease is early-onset autosomal dominant Alzheimer disease.