In consistent with the role of macrophage LRP-1 in atherosclerosis, study using mice with conditional deletion of LRP-1 in vSMCs also supports the protective effect of vSMC LRP-1, which showed that vSMC LRP-1-deficient mice display hyperplasia of aortal wall, disruption of elastic lamina, and formation of aortic aneurysm, and are highly susceptible to atherosclerosis [86]. Here, LRP1 is linked to aortic aneurysm.