Based on the fact that curcumin overcomes chemoresistance and sensitizes multiple myeloma cells to thalidomide and bortezomib by downregulating NF-κB and NF-κB-regulated genes [127], recent studies focused on the design and biological characterization of hybrid compounds associating curcumin with these two molecules [128]. The gene discussed is NFKB1; the disease is plasma cell myeloma.