Children with HSP with hemafecia had lower IgG (Z = −2.862, P = 0.004), IgM (Z = −2.26, P = 0.024), CD4+ cells (Z = −2.467, P = 0.014), and ratio of CD4+/CD8+ (Z = −2.416, P = 0.016) than children without hemafecia (Fig. 3). Here, CD8A is linked to hereditary spastic paraplegia.