Similar to these effects on DAT hyperactivity, while administration of psychostimulant drugs to WT mice impairs PPI, the deficits in PPI found in DAT KO mice are reversed by administration of psychostimulant drugs that treat ADHD [17], the selective norepinephrine reuptake blocker nisoxetine [17], and nicotine [64]. Here, SLC6A3 is linked to attention deficit-hyperactivity disorder.