(1) In angiotensin II models of hypertension, flow responses are indeed attenuated in some organs prior to the development of increased blood pressure [89], suggesting that the increased peripheral resistance in hypertension represents a systemic response to preserve tissue oxygenation in response to widespread capillary/pericyte constrictions and elevated CTH in response to this powerful pericyte constrictor. This evidence concerns the gene CTH and hypertensive disorder.