COX-2 protein expression failed to show an association with age at diagnosis (P = 0.708) (Additional file 1: Table S8A), tumor size (P = 0.508) (Additional file 1: Table S8B), histologic grading (P = 0.904) (Additional file 1: Table S8C), hormone receptor status (P = 0.125) (Additional file 1: Table S8D), PR (P = 0.773) (Additional file 1: Table S8E) or HER2 status (P = 0.453) (Additional file 1: Table S8F). This evidence concerns the gene NR4A1 and neoplasm.