For transplantation with unmanipulated CD34+ cells as well as DLIs a starting dose of <2.5 × 104 CD3+ T cells/kg is recommended in a haploidentical setting and <105 CD3+ T cells/kg in a HLA-matched setting to reduce the risk of inducing or enhancing GvHD [35]. The gene discussed is CD34; the disease is graft versus host disease.