VIM and cancer: Confocal microscopy analyses confirmed, as previously described [26], more aggressive features for MIA PaCa-2 and PANC-1 as, differently from BxPC-3 and CAPAN-2, these cancer cells possess a marked mesenchymal phenotype characterized by up-regulation of the mesenchymal marker vimentin and down-regulation of the epithelial marker E-cadherin (Figure 1B,C,D) [28].