ERBB2 and invasive breast carcinoma: MMPs and TIMPs, which are known to be involved in breast carcinogenesis (MMP-1, 2, 7, 9, 11, 13, and 14 and TIMP-1, 2, and 3), were selected and assessed using the immunohistochemistry of three major subtypes of invasive breast carcinomas (luminal A, basal-like, and HER2-overexpressing); based on the immunohistochemical findings of ER-α, PR, HER2, EGFR, and CK5/6.