We found that i) L1CAM is preferentially but not exclusively expressed in TNBCs; ii) L1CAM expression is inversely correlated with the expression of AR in three independent breast cancer cohorts; iii) L1CAM and AR are inversely correlated in breast cancer cell lines and over-expression of AR down-regulates L1CAM expression in MDA-MB436 cells; iv) upon over-expression AR binds to AR response elements in the L1CAM promoter as revealed by CHIP-analysis. This evidence concerns the gene L1CAM and breast cancer.