However, more importantly, it can be explained by a study performed by Cao et al., in which RAET1E was able to produce soluble protein lacking a transmembrane region that weakened NKG2D-mediated NK cell cytotoxicity to tumor cells, despite that RAET1E and RAET1G contain both transmembrane and cytoplasmic domains [34]. Here, KLRK1 is linked to neoplasm.