ICMT and progeroid syndrome: Several studies have shown that cells or mouse models of progeria after treatment with either farnesyltransferase inhibitor (FTI), statins, or isoprenylcysteine carboxyl methyltransferase (ICMT) inhibitor could reverse some of the phenotypic changes occurring in these cells or tissues (Fong et al., 2006; Capell et al., 2008; Yang et al., 2008; Ibrahim et al., 2013).