LMNA and Hutchinson-Gilford progeria syndrome: Progerin consequently is tightly anchored to the nuclear envelope, disrupting the nuclear lamina and causing nuclear blebbing, heterochromatin disorganization, and accumulation of DNA double-strand breaks (DSB) in HGPS patient cells, as well as in cells in which the progerin is expressed by transgenic methods (Goldman et al., 2004; Liu et al., 2006; Manju et al., 2006; Gordon et al., 2014).