Figure S1A (Supporting information) shows the maximum-likelihood phylogenetic tree from TreeFam. HYPK is of great interest due to its prior association with Huntington's disease, where it appears to play a protective role (Arnesen et al., 2010), whereas SERF2 is predicted to promote aggregation, like CRAM-1, offering a better target for intervention. The gene discussed is HYPK; the disease is juvenile Huntington disease.