MTOR and non-small cell lung carcinoma: For example, in NSCLC H1299 cells apoptosis was induced through suppression of the nuclear factor (NF)-κB activation pathway [10]; and in pancreatic SW1990 cells, apoptosis was induced via regulation of the PI3 K/Akt pathway [22], in 253J and T24 bladder cancer cells, apoptosis was induced through mTOR/S6K1-mediated downregulation of Mcl-1 [8].