AGRN and hepatocellular carcinoma: Among the main heparan sulfate PGs (HSPG), identified in basement membrane, are agrin and perlecan, which not only were reported to be overexpressed in some cancers, such as prostate cancer [11], hepatocellular carcinoma [12] and breast cancer [13], but also had their function associated with tumorigenic events [10], [14], [15].