In this context, the major findings of our current study performed on a model of mild asthma induced by OVA are the following: (i) i.n. pre-treatment with recombinant TRAIL significantly counteracted the increase of infiltrating leukocytes, and in particular of neutrophils and eosinophils, in BAL of OVA-treated mice. The gene discussed is TNFSF10; the disease is asthma.