For example, IL8 expression has been shown to be under expressed in patients post imatinib treatment and miR-493-5p has been implicated in colon metastasis [35], [36], bladder cancer [37], ovarian cancer [38] and triple negative breast cancer [39]; however, the regulatory connection between this gene/miRNA pair or their functional connection to imatinib sensitivity is unknown. The gene discussed is CXCL8; the disease is urinary bladder cancer.