CSF2 and melanoma: By using intratumoral injections of bacterial superantigen gene (staphylococcal enterotoxin B, SEB) as immune-adjuvant plus the immunostimulatory gene canine GM-CSF, the objective responses and median survivals for spontaneous canine melanoma were as follows: stage I, 3/3-427 days; stage II, 3/5-399 days; stage III, 4/12-168 days; stage IV, 0/2-n.d.