It was proposed that the adaptor protein CrkII associates with Abl during infection, as evidenced by the presence of CrkII at the site of active Salmonella internalization where it colocalized with F-actin. Salmonella infection led to increased phosphorylation of CrkII, while CrkII phosphorylation deficient variants block Salmonella entry. The gene discussed is CRK; the disease is Salmonella Infections.