Besides rare cases of germline mutations of the Fumarate Hydratase (FH) gene [3] associated with an early onset of cutaneous and uterine UL as well as with renal cancer or of Col genes [4], two frequent types of independent somatic driver mutations have been deduced i.e. rearrangements of high mobility group protein gene 2 (HMGA2) [5] and, much more frequently those affecting MED12 [1]. The gene discussed is FH; the disease is renal carcinoma.