For example, Lado-Abeal and colleagues identified a mildly elevated serum PRL in 20% of women with Cushing's disease and menstrual abnormalities [3], and both Mahler et al. [4] and Sherry et al. [5] have presented a patient with Cushing's disease and symptomatic hyperprolactinemia. This evidence concerns the gene PRL and hyperprolactinemia.