EP activated cleaved PARP, Bax and caspase 8/3, and attenuated the expression of procaspase 8, Bcl-2, Bcl-XL without affecting procaspase 9 from the concentration of 25 μM compared to untreated control in DU 145 prostate cancer cells as shown Figure 3a, and b. This evidence concerns the gene CASP8 and Familial prostate cancer.