Western blotting showed that EP cleaved PARP and caspase 8/3 without affecting caspase 9, attenuated the expression of anti-apoptotic proteins such as c-FLIP, Bcl-XL and Bcl-2 as well as activated the expression of proapoptotic protein Bax, FADD and DR 5 in a concentration dependent manner in DU 145 prostate cancer cells, strongly demonstrating death receptor dependent apoptosis by EP in DU 145 prostate cancer cells. Here, CASP8 is linked to Familial prostate cancer.