CCNE1 and cancer: Premature hyperactivation of CDC25C in human cancer cells via phosphorylation on S214, as observed in cells overexpressing low molecular weight isoforms of cyclin E, has indeed been associated with premature mitotic entry, deregulation of G2-M transition, abrogation of the NOC-mediated mitotic arrest, emergence of centrosome amplification with emergence of cells with supernumerary centrosomes, multipolar anaphase spindles, chromosome missegregation, and polyploidy due to a cytokinesis failure (Bagheri-Yarmand et al., 2010b).