Therefore, in this work, we selected polymorphisms rs1800587 (c.-949C>T) of IL1A and rs2228570 (c.2T>V) and rs731236 (c.1056T>C) of VDR to evaluate their potential association with lumbar IDD in a Mestizo population from Sinaloa, a northwestern state from México. This evidence concerns the gene VDR and intervertebral disk degenerative disorder.